Evaluation of fractalkine (FKN) and secreted frizzled-related protein 4 (SFRP-4) serum levels in patients with prediabetes and type 2 diabetes
نویسندگان
چکیده
منابع مشابه
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in human pancreatic islets. A group of coexpressed genes (module), enriched for interleukin-1-related genes, was associated with T2D and reduced insulin secre...
متن کاملAssociation of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease
BACKGROUND Secreted frizzled-related proteins (SFRP) are regulators of Wnt-signalling. SFRP4 has been shown to regulate insulin exocytosis and is overexpressed in type 2 diabetes mellitus. Here we characterized the relation of SFRP4 to glucose and triglyceride metabolism and outcomes in patients with stable coronary artery disease on statin treatment in the prospective Homburg Cream & Sugar Stu...
متن کاملSecreted Frizzled - related protein 2 ( sFRP 2 ) as a target 2 in anti - fibrotic therapeutic intervention 3 4
22 23 24 Progressive fibrosis is a pathological hallmark of many chronic diseases responsible for 25 organ failure. Although there is currently no therapy on the market that specifically targets 26 fibrosis, the dynamic fibrogenic process is known to be regulated by multiple soluble mediators 27 that may be therapeutically intervened. The failing hamster heart exhibits marked fibrosis and 28 in...
متن کاملimmunohistochemical analysis and role of secreted frizzled-related protein-4 in polycystic ovary-induced rat
objective: the role of wnt signaling and its antagonist; secreted frizzled related protein type 4 (sfpr4) was reported in rodent ovarian follicular development. this study examines immunolocalization of sfrp4 in ovaries of polycystic ovary (pco) rat model and evaluates its role in follicular growth arrest and its premature differentiation. materials and mathods: pco was induced with daily admin...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2018
ISSN: 1336-0345
DOI: 10.4149/bll_2018_021